medication dosing and safety

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Medication Dosing and Safety

Route of administration and rate of absorption both factor into the safety of a drug by impacting how quickly the drug acts and how much of the drug is actively available or excreted without being used. Age, metabolism, and body weight also impact dosing and safety issues, as do other medications, food, and health issues. Carefully consider these safety concerns during your readings this week.

Note: For this week, students should start their research for their Assignment before the Discussion. For the most effective use of your time and research, the Assignment and Discussion should be worked on in tandem.

Select a medication relevant to this course. Research online for the medication package insert or label. (Typically a PDF version of the package insert or label information can be found on the drug company’s website.) Review the package insert and address the following:

Post by Day 4 an explanation of the routes of administration, pharmacokinetics, and pharmacodynamics of the medication you selected for your Assignment.

Explain how routes of administration, dose-response curves, ED50, and LD50 interact. (Think about how “route” relates to “rate” to answer the question.)

Then, explain the potential implications for drug safety.

Use specific examples from the medication you chose for this Assignment to support your answer.

Readings

  • Advokat, C. D., & Comaty, J. E., & Julien, R. M. (2019). Julien’s primer of drug action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs (14th ed.). New York, NY: Worth Publishers/Macmillan.
    • Chapter 1, “Pharmacokinetics: How Drugs Are Handled by the Body” (pp. 1-36)
    • Chapter 3, “Pharmacodynamics: How Drugs Act” (pp. 36-97)
  • Hancock, S. D, & McKim, W. A. (2018). Drugs and behavior: An introduction to behavioral pharmacology (8th ed.). Upper Saddle River, NJ: Pearson.
    • Chapter 1, “Some Basic Pharmacology” (pp. 1–21)
  • Noble, M., Tregear, S. J., Treadwell, J. R., & Schoelles, K. (2008). Long-term opioid therapy for chronic noncancer pain: A systematic review and meta-analysis of efficacy and safety. Journal of Pain and Symptom Management, 35(2), 214–228.
    Retrieved from the Walden Library databases.
  • U.S. Department of Health and Human Services, U.S. Food and Drug Administration. (2013, March). Drugs: Information by drug class. Retrieved from http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/default.htm
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